Part I: The Development of the Catalytic Wittig Reaction

CJ O'Brien, ZS Nixon, AJ Holohan…

Index: O'Brien, Christopher J.; Nixon, Zachary S.; Holohan, Andrew J.; Kunkel, Stephen R.; Tellez, Jennifer L.; Doonan, Bryan J.; Coyle, Emma E.; Lavigne, Florie; Kang, Lauren J.; Przeworski, Katherine C. Chemistry - A European Journal, 2013 , vol. 19, # 45 p. 15281 - 15289

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Citation Number: 26

Abstract

Abstract We have developed the first catalytic (in phosphane) Wittig reaction (CWR). The utilization of an organosilane was pivotal for success as it allowed for the chemoselective reduction of a phosphane oxide. Protocol optimization evaluated the phosphane oxide precatalyst structure, loading, organosilane, temperature, solvent, and base. These studies demonstrated that to maintain viable catalytic performance it was necessary to employ ...