Biological & Pharmaceutical Bulletin 1995-04-01

Columbin isolated from calumbae radix affects the sleeping time of anesthetized mice.

K Wada, T Kurihara, M Yagi, R Kobayashi, H Kaminaga, K Toi, M Haga

Index: Biol. Pharm. Bull. 18(4) , 634-6, (1995)

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Abstract

In a screening series of bioactive components in edible and medicinal plants, we found that Calumbae Radix (Colombo root, 1% powdered feed, for 5 d) and its component, columbin (20-40 mg/kg/d, for 5 d, orally), shortened the sleeping time induced by a urethane and alpha-chloralose mixture and prolonged the sleeping time induced by hexobarbital in mice.