Chemistry: A European Journal 2010-10-11

A concise total synthesis of amphidinolide T2.

Huoming Li, Jinlong Wu, Jialu Luo, Wei-Min Dai

Index: Chemistry 16(38) , 11530-4, (2010)

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Abstract

RCM + AD = T2: In the presence of the C16-methylene group, regioselective ring-closing metathesis (RCM) formed the (12E)-endocyclic double bond, which underwent Os-catalyzed asymmetric dihydroxylation (AD) to give the desired 12,13-diol intermediate required for the total synthesis of amphidinolide T2 in 16 linear steps in 8.0% overall yield.Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.