Chemical Communications 2012-01-25

Exonuclease-assisted cascaded recycling amplification for label-free detection of DNA.

Sai Bi, Li Li, Yangyang Cui

Index: Chem. Commun. (Camb.) 48(7) , 1018-20, (2012)

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Abstract

The network consisting of three kinds of unlabeled stem-loop DNA molecular beacons (MBs) is activated by target DNA in the presence of exonuclease-III (Exo-III), achieving the concept of exonuclease-assisted cascaded recycling amplification (Exo-CRA) for DNA detection with a wide dynamic range of 8 orders of magnitude.This journal is © The Royal Society of Chemistry 2012