Organic Letters 2013-12-20

Total synthesis of human galanin-like peptide through an aspartic acid ligation.

Xiaoyang Guan, Matthew R Drake, Zhongping Tan

Index: Org. Lett. 15(24) , 6128-31, (2013)

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Abstract

Human galanin-like peptide (hGALP) is a newly discovered hypothalamic peptide that plays important roles in the regulation of food intake and energy balance. Here, we demonstrate that the aspartic acid ligation can be employed to achieve an efficient synthesis of hGALP. The total synthesis of hGALP enhances our ability to study its biology and facilitates the development of more stable analogues.