Journal of Natural Products 2008-04-01

Citrinin dimers from the halotolerant fungus Penicillium citrinum B-57.

Zhen-Yu Lu, Zhen-Jian Lin, Wen-Liang Wang, Lin Du, Tian-Jiao Zhu, Yu-Chun Fang, Qian-Qun Gu, Wei-Ming Zhu

Index: J. Nat. Prod. 71 , 543-6, (2008)

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Abstract

In order to search for structurally novel and bioactive natural compounds from microorganisms, a halotolerant fungal strain, Penicillium citrinum B-57, which mainly produces citrinin derivatives, was isolated from sediments collected from the Jilantai salt field. From the ethyl acetate extract of P. citrinum B-57, two new citrinin dimers, pennicitrinone C ( 1) and penicitrinol B ( 2), and 11 known related compounds were isolated and identified by spectroscopic and chemical methods. These compounds showed antioxidative activity against DPPH radicals with IC 50 values ranging from 0.8 to 59 microM.