Potent inhibitors of the hepatitis C virus NS3 protease: design and synthesis of macrocyclic substrate-based β-strand mimics

…, AM Faucher, JM Ferland, C Grand-Maître…

Index: Faucher, Anne-Marie; White, Peter W.; Brochu, Christian; Grand-Maitre, Chantal; Rancourt, Jean; Fazal, Gulrez Journal of Medicinal Chemistry, 2004 , vol. 47, # 1 p. 18 - 21

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Citation Number: 72

Abstract

The virally encoded NS3 protease is essential to the life cycle of the hepatitis C virus (HCV), an important human pathogen causing chronic hepatitis, cirrhosis of the liver, and hepatocellular carcinoma. The design and synthesis of 15-membered ring β-strand mimics which are capable of inhibiting the interactions between the HCV NS3 protease enzyme and its polyprotein substrate will be described. The binding interactions between a macrocyclic ...