Abstract: The rates of ring inversion and conformational equilibration of 6, 6-difluoro-cis- decal-2-one and 10-methyl-6, 6-difluoro-cis-decal-2-one have been determined using fluorine magnetic resonance spectroscopy. The activation energies were found to be 11.3 i. 0.3 and 9.5= k 0.1 kcal/mol, respectively. 4, 4-Difluorocyclohexanone, however, appears to exchange its fluorines between conformationally nonequivalent sites rapidly on the nmr ...
