Chemistry: A European Journal 2012-07-16

Copper-catalyzed synthesis of quinazolines in water starting from o-bromobenzylbromides and benzamidines.

Chandi C Malakar, Alevtina Baskakova, Jürgen Conrad, Uwe Beifuss

Index: Chemistry 18(29) , 8882-5, (2012)

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Abstract

Water makes it possible: The Cu(2)O-catalyzed reaction between easily available o-bromobenzylbromides and benzamidines by using Cs(2)CO(3) as the base and N,N'-dimethylethylenediamine (DMEDA) as the additive in water as the solvent gives access to substituted quinazolines in a single step with yields ranging from 57 to 85 % (see scheme).Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.