Journal of the American Chemical Society

. alpha.-Silylated vinyl ketones. New class of reagents for the annelation of ketones

G Stork, B Ganem

Index: Stork,G.; Ganem,B. Journal of the American Chemical Society, 1973 , vol. 95, p. 6152 - 6153

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Citation Number: 147

Abstract

The annelation of 2-alkylcyclohexanones with methyl vinyl ketone and its homologs is an important route to fused polycyclic systems. While condensation at the less substituted a carbon can be carried out efficiently using the corresponding enamines, the conditions required for reaction at the more substituted site result in polymerization of the vinyl ketone and generally low yields. This type of difficulty is avoided a:+ 70

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