Molecular Biology Reports 2015-05-01

The biological effects of hsa-miR-1908 in human adipocytes.

Lei Yang, Chun-mei Shi, Ling Chen, Ling-xia Pang, Guang-feng Xu, Nan Gu, Li-jun Zhu, Xi-rong Guo, Yu-hui Ni, Chen-bo Ji

Index: Mol. Biol. Rep. 42(5) , 927-35, (2015)

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Abstract

MicroRNAs (miRNAs) are small non-coding RNAs involved in the regulation of gene expression. MiR-1908 is a recently identified miRNA that is highly expressed in human adipocytes. However, it is not known what role of miR-1908 is involved in the regulation of human adipocytes. In this study, we demonstrate that the level of miR-1908 increases during the adipogenesis of human multipotent adipose-derived stem (hMADS) cells and human preadipocytes-visceral. Overexpression of miR-1908 in hMADS cells inhibited adipogenic differentiation and increased cell proliferation, suggesting that miR-1908 is involved in the regulation of adipocyte cell differentiation and metabolism, and, thus, may have an effect on human obesity.