Bioorganic & Medicinal Chemistry 2010-01-01

Design of more potent squalene synthase inhibitors with multiple activities

Angeliki P. Kourounakis, Alexios N. Matralis, Anastasios Nikitakis, Angeliki P. Kourounakis, Alexios N. Matralis, Anastasios Nikitakis

Index: Bioorg. Med. Chem. 18 , 7402-12, (2010)

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Abstract

Antihyperlipidemic morpholine derivatives ( 1– 6), combining several pharmacophore moieties, were evaluated in vitro and in vivo and optimized towards more active SQS inhibitors ( 7– 12).