Xenobiotica 2000-12-01

Metabolism of N-isopropylacetanilide in rat.

G L Larsen, V J Feil, J E Bakke

Index: Xenobiotica 30(12) , 1153-7, (2000)

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Abstract

1. Radioactivity from oral doses of N-isopropyl[1-14C]acetanilide was excreted in urine (53.5%), faeces (8.1%) and expired air (17.0%) of rat. 2. Enterohepatic circulation occurred during formation of approximately 34% of the metabolites. N-isopropylacetanilide was metabolized by oxidation in all moieties of the molecule with subsequent conjugation with glucuronic and sulphuric acids. 3. The sulphate ester of 4'-hydroxyacetanilide (acetaminophen) was the major metabolite (28 % of the dose).