Journal of Natural Products 2005-09-01

Antitubercular constituents from the stem wood of Cinnamomum kotoense.

Fu-Chi Chen, Chien-Fang Peng, Ian-Lih Tsai, Ih-Sheng Chen

Index: J. Nat. Prod. 68 , 1318-23, (2005)

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Abstract

Five new compounds, kotolactone A (1), kotolactone B (2), secokotomolide (3), kotodiol (4), and 2-acetyl-5-dodecylfuran (5), and 36 known compounds have been isolated from the stem wood of Cinnamomum kotoense. The structures of these new compounds were determined by means of spectroscopic analysis. The known butanolides, isoobtusilactone A (6) and lincomolide B (7), showed in vitro antitubercular activities with MIC values of 22.48 and 10.16 microM, respectively, against Mycobacterium tuberculosis 90-221387.