Organic Letters 2007-02-15

Ru-catalyzed intermolecular [3+2+1] cycloaddition of alpha,beta-unsaturated ketones with silylacetylenes and carbon monoxide leading to alpha-pyrones.

Takahide Fukuyama, Yuki Higashibeppu, Ryo Yamaura, Ilhyong Ryu

Index: Org. Lett. 9 , 587, (2007)

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Abstract

Ruthenium catalyzes a carbonylative [3+2+1] cycloaddition, using silylacetylenes, alpha,beta-unsaturated ketones, and CO as the starting materials, providing the new method for the synthesis of tetrasubstituted alpha-pyrones. In this reaction, the carbonyl group and alpha-carbon of vinyl ketones are incorporated as a three-atom assembling unit. [reaction: see text].

Structure	Name/CAS No.	Molecular Formula	Articles
	Carbon monooxide-ruthenium (4:1) CAS:15243-33-1	C₁₂O₁₂Ru₃

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Ragaini, F. et al.
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Ru-catalyzed intermolecular [3+2+1] cycloaddition of alpha,beta-unsaturated ketones with silylacetylenes and carbon monoxide leading to alpha-pyrones.

Abstract

Related Compounds