Natural product communications 2010-04-01

Biotransformation of alpha-cedrol and caryophyllene oxide by the fungus Neurospora crassa.

Ismail Kiran, Zeynep Durceylan, Neşe Kirimer, K Hüsnü Can Baser, Yoshiaki Noma, Fatih Demirci

Index: Nat. Prod. Commun. 5(4) , 515-8, (2010)

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Abstract

Incubation of alpha-cedrol and caryophyllene oxide with Neurospora crassa afforded 12beta-hydroxy cedrol, 10alpha-hydroxy cedrol, and 3beta-hydroxy cedrol, and 12beta-hydroxy caryophyllene oxide as major metabolites, respectively. The antibacterial and radical scavenging activities of the metabolites were evaluated in vitro using broth microdilution and bioauthographic techniques. However, no significant antibacterial and antioxidant activities were observed when compared with those of standard substances.