Cancer Letters 2015-09-28

Anti-metastatic outcome of isoform-specific prolactin receptor targeting in breast cancer

Tomohiro Yonezawa, Kuan-Hui (Ethan) Chen, Mrinal K. Ghosh, Lorena Rivera, Riva Dill, Lisa Ma, Pedro A. Villa, Mitsumori Kawaminami, Ameae M. Walker

Index: Cancer Lett. 366 , 84-92, (2015)

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Abstract

• The work establishes a crucial role for the long prolactin receptor in metastatic spread of breast cancer. • The spice-modulating agent has potential as a well-tolerated cancer therapeutic. • The principle of isoform-specific knockdown can be applied to multiple targets in breast and other cancers.