Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 1983-12-01

Dominant lethal effects of n-butyl glycidyl ether in mice.

E B Whorton, T G Pullin, A F Frost, A Onofre, M S Legator, D S Folse

Index: Mutat. Res. 124(3-4) , 225-33, (1983)

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Abstract

Using the dominant lethal assay, the ability of n-butyl glycidyl ether to induce mutations in male mice was investigated. No significant dose-related changes either in pregnancy rates or in average number of implants per pregnant female were found. However, while the results were not altogether conclusive, there was evidence of a significant increase in fetal death rates by the end of the first week after the highest dosage was administered.