Organic letters

Palladium-catalyzed inter-and intramolecular coupling reactions of aryl and vinyl halides mediated by indium

PH Lee, D Seomoon, K Lee

Index: Phil, Ho Lee; Seomoon, Dong; Lee, Kooyeon Organic Letters, 2005 , vol. 7, # 2 p. 343 - 345

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Citation Number: 54

Abstract

Treatment of aryl and vinyl halides with 50 mol% of 100 mesh indium, 2.5 mol% of Pd-C, and 1.5 equiv of LiCl under mild conditions (DMF, 100° C, 1-3 h) could produce coupling products efficiently in good to excellent yields in which the Csp2-Csp2 bond was formed. This reagent worked equally well with both intermolecular and intramolecular coupling reactions, producing a variety of biaryls, 1, 3-dienes, and cyclic compounds.