Human & Experimental Toxicology 1994-12-01

Changes in debrisoquine hydroxylation capacity following liver surgery.

SC Mitchell, RR Shah, DG Clements, RL Smith

Index: Hum. Exp. Toxicol. 13(8) , 537-41, (1994)

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Abstract

Liver transplantation or the surgical construction of portacaval shunts may radically alter an individual's debrisoquine hydroxylation capacity. Good clinical management should encompass a full awareness of such changing needs and problems in patients who undergo hepatic surgery.