Regioselective chlorination and bromination of unprotected anilines under mild conditions using copper halides in ionic liquids

H Wang, K Wen, N Nurahmat, Y Shao…

Index: Wang, Han; Wen, Kun; Nurahmat, Nurbiya; Shao, Yan; Zhang, He; Wei, Chao; Li, Ya; Shen, Yongjia; Sun, Zhihua Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 744 - 748

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Citation Number: 10

Abstract

Abstract By using ionic liquids as solvents, the chlorination or bromination of unprotected anilines at the para-position can be achieved in high yields with copper halides under mild conditions, without the need for potentially hazardous operations such as supplementing oxygen or gaseous HCl.