Journal of Chromatography A 2006-01-01

A new silylating reagent–dimethyl(3,3,3-trifluoropropyl)silyldiethylamine–for the derivatisation of non-steroidal anti-inflammatory drugs prior to gas chromatography-mass spectrometry analysis

Magda Caban, Katarzyna Mioduszewska, Paulina Łukaszewicz, Natalia Migowska, Piotr Stepnowski, Marek Kwiatkowski, Jolanta Kumirska

Index: J. Chromatogr. A. 1346 , 107-16, (2014)

Full Text: HTML

Abstract

• DIMETRIS–a new silylating reagent for the derivatisation of NSAIDs. • Derivatising properties of DIMETRIS compared with those of BSTFA and TMSD. • Possibility of using MS and ECD detectors for the GC determination of new derivatives. • Study of the influence of complex matrices on derivatisation and GC-MS analysis. • A new SPE-GC-MS method for determining NSAIDs based on derivatisation with DIMETRIS