Bioorganic & Medicinal Chemistry 2008-01-01

Synthesis and cytotoxic activities of usnic acid derivatives

Marc-Antoine Bazin, Anne-Cécile Le Lamer, Jean-Guy Delcros, Isabelle Rouaud, Philippe Uriac, Joël Boustie, Jean-Charles Corbel, Sophie Tomasi, Marc-Antoine Bazin, Anne-Cécile Le Lamer, Jean-Guy Delcros, Isabelle Rouaud, Philippe Uriac, Joël Boustie, Jean-Charles Corbel, Sophie Tomasi

Index: Bioorg. Med. Chem. 16 , 6860-6, (2008)

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Abstract

Cytotoxic evaluation of enamines derived from (+)-usnic acid led us to the selection of the diaminooctane derivative as active towards cancer cell lines (2.7 < IC 50 < 14.1 μM). Apoptotic effect was also observed.