Synthesis of new azulene derivatives and study of their effect on lipid peroxidation and lipoxygenase activity.

…, M Chrysselis, I Siskou, A Kourounakis

Index: Rekka, Eleni; Chrysselis, Michael; Siskou, Ioanna; Kourounakis, Angeliki Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 7 p. 904 - 907

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Citation Number: 39

Abstract

The relationship between free radicals and acute or chronic inflammation has been well established. We have previously reported the significant antioxidant activity of the natural azulene derivatives chamazulene and guaiazulene. Furthermore, some synthetic azulene analogues have been found to possess anti-inflammatory activity. In this investigation we report the synthesis of five 3-alkyl or 3-(hydroxy) alkylazulene-1-carboxylic acids and ...