Synthesis of novel 5-substituted indirubins as protein kinases inhibitors

A Beauchard, Y Ferandin, S Frère, O Lozach…

Index: Beauchard, Anne; Ferandin, Yoan; Frere, Stephane; Lozach, Olivier; Blairvacq, Melina; Meijer, Laurent; Thiery, Valerie; Besson, Thierry Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 18 p. 6434 - 6443

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Citation Number: 83

Abstract

In an effort to identify new pharmacological inhibitors of disease-relevant protein kinases with increased potency and selectivity, we synthesized and evaluated new 5-substituted indirubins. The effects of 34 indirubin derivatives on CDK1/cyclin B, CDK5/p25, and GSK-3, as well as on SH-SY5Y human neuroblastoma cell survival, were investigated.