Angewandte Chemie International Edition

A General Method for the Direct α??Arylation of Nitriles with Aryl Chlorides

J You, JG Verkade

Index: You, Jingsong; Verkade, John G. Angewandte Chemie - International Edition, 2003 , vol. 42, # 41 p. 5051 - 5053

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Citation Number: 105

Abstract

Jingsong You and John G. Verkade* α-Aryl-substituted nitriles are not only important building blocks for constructing pyridines, carboxylic acids, primary amines, bicyclic amidines, lactones, aldehydes, and esters,[1] but also for synthesizing biologically active compounds.[2] However, the synthesis of α-aryl nitriles by direct α-arylation of nitriles has been sufficiently difficult, that the development of chemistry that could emanate from a ...