Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase

…, LA Fothergill-Gilmore, PAM Michels…

Index: Brimacombe, Kyle R.; Walsh, Martin J.; Liu, Li; Vasquez-Valdivieso, Montserrat G.; Morgan, Hugh P.; McNae, Iain; Fothergill-Gilmore, Linda A.; Michels, Paul A. M.; Auld, Douglas S.; Simeonov, Anton; Walkinshaw, Malcolm D.; Shen, Min; Boxer, Matthew B. ACS Medicinal Chemistry Letters, 2014 , vol. 5, # 1 p. 12 - 17

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Citation Number: 6

Abstract

Human African Trypanosomiasis (HAT) is a severe, often fatal disease caused by the parasitic protist Trypanosoma brucei. The glycolytic pathway has been identified as the sole mechanism for ATP generation in the infective stage of these organisms, and several ...