Phytochemistry 2015-11-01

Jubanines F-J, cyclopeptide alkaloids from the roots of Ziziphus jujuba.

Kyo Bin Kang, Gao Ming, Geum Jin Kim, Thi-Kim-Quy Ha, Hyukjae Choi, Won Keun Oh, Sang Hyun Sung

Index: Phytochemistry 119 , 90-5, (2015)

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Abstract

Five Ib-type cyclopeptide alkaloids, jubanines F-J (1-5), and three known compounds, nummularine B (6), daechuine-S3 (7), and mucronine K (8) were isolated from the roots of Ziziphus jujuba. Their structures were fully characterized by spectroscopic analyses in combination with chemical derivatization. Compounds 1-3, and 6 were evaluated for their antiviral activity against the porcine epidemic diarrhea virus (PEDV). Compounds 2, 3, and 6 showed potent inhibitory effects on PEDV replication. Copyright © 2015 Elsevier Ltd. All rights reserved.