Oxidative Medicine & Cellular Longevity 2013-01-01

Potentiation of antibiofilm activity of amphotericin B by superoxide dismutase inhibition.

Katrijn De Brucker, Anna Bink, Els Meert, Bruno P A Cammue, Karin Thevissen

Index: Oxid. Med. Cell. Longev. 2013 , 704654, (2013)

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Abstract

This study demonstrates a role for superoxide dismutases (Sods) in governing tolerance of Candida albicans biofilms to amphotericin B (AmB). Coincubation of C. albicans biofilms with AmB and the Sod inhibitors N,N'-diethyldithiocarbamate (DDC) or ammonium tetrathiomolybdate (ATM) resulted in reduced viable biofilm cells and increased intracellular reactive oxygen species levels as compared to incubation of biofilm cells with AmB, DDC, or ATM alone. Hence, Sod inhibitors can be used to potentiate the activity of AmB against C. albicans biofilms.