Food and Chemical Toxicology 2011-08-01

A 13-week subchronic toxicity study of hinokitiol administered in the diet to F344 rats

Y.M. Cho, M. Hasumura, S. Takami, T. Imai, M. Hirose, K. Ogawa, A. Nishikawa

Index: Food Chem. Toxicol. 49(8) , 1782-6, (2011)

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Abstract

Highlights ► A 13-week dietary toxicity study of hinokitiol is performed for re-evaluation. ► The no-observed-adverse-effect level for male and female F344 rats is 12.7 and 14.8mg/kgb.w./day, respectively. ► Myocarditis observed in previous studies is not evident.