Journal of the American Chemical Society

Certain Derivatives of 2, 5-Dihydroxyphenylacetic Acid

RW Bost, CA Howe

Index: Bost; Howe Journal of the American Chemical Society, 1952 , vol. 74, p. 257

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Abstract

Experimental 2,5-Dialkoxyacetophenones.-The general method of Abbott and Smitha for the preparation of 2,Mimethoxy- acetophenone by the Friedel-Crafts acylation of 1,4-di- methoxybenzene was used. In the case of the di-n-pro- poxp- and di-n-butoxy-compounds, better yields were ob- tained if the aluminum chloride complex was hydrolyzed three hours after combination of the reactants was com- pleted rather than allowing the mixture to stand overnight. * ...