Scientific reports 2015-01-01

Quantitative activation-induced manganese-enhanced MRI reveals severity of Parkinson's disease in mice.

Satomi Kikuta, Yukiyo Nakamura, Yukio Yamamura, Atsushi Tamura, Noriyasu Homma, Yuchio Yanagawa, Hajime Tamura, Jiro Kasahara, Makoto Osanai

Index: Sci. Rep. 5 , 12800, (2015)

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Abstract

We demonstrate that activation-induced manganese-enhanced magnetic resonance imaging with quantitative determination of the longitudinal relaxation time (qAIM-MRI) reveals the severity of Parkinson's disease (PD) in mice. We first show that manganese ion-accumulation depends on neuronal activity. A highly active region was then observed by qAIM-MRI in the caudate-putamen in PD-model mice that was significantly correlated to the severity of PD, suggesting its involvement in the expression of PD symptoms.