Bioorganic & Medicinal Chemistry 2008-04-01

Gamma-carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity.

Kumiko Sako, Hiroshi Aoyama, Shinichi Sato, Yuichi Hashimoto, Masanori Baba

Index: Bioorg. Med. Chem. 16 , 3780, (2008)

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Abstract

Based on anti-viral screening of our heteroaromatics derived from thalidomide, the gamma-carboline skeleton has been identified as a superior scaffold structure for compounds with potent anti-bovine viral diarrhea virus (BVDV) activity. Structural development studies led to a potent anti-viral agent, SK5M (5-methyl-gamma-carboline), with the EC(50) of 0.26 microM.