Bioorganic & Medicinal Chemistry Letters 2012-09-01

Fluorescence sensing of caffeine in aqueous solution with carbazole-based probe and imaging application in live cells.

Ajit Kumar Mahapatra, Jagannath Roy, Prithidipa Sahoo, Subhra Kanti Mukhopadhyay, Anindita Roy Mukhopadhyay, Debasish Mandal

Index: Bioorg. Med. Chem. Lett. 22(17) , 5379-83, (2012)

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Abstract

The host-guest interaction of caffeine in aqueous solutions has been achieved by using carbazole based imino-phenol receptors with oxopurines influences their fluorescence properties and can be exploited for 'turn-ON' fluorescence sensing of caffeine. This new fluorescent probe with high sensitivity and selectivity for detection and first time imaging of caffeine in living cells was developed in aqueous media.Copyright © 2012 Elsevier Ltd. All rights reserved.