Bioorganic & Medicinal Chemistry Letters 2009-04-01

Semi-synthetic analogs of pinitol as potential inhibitors of TNF-alpha cytokine expression in human neutrophils.

Khurshid A Bhat, Bhahwal A Shah, Kuldeep K Gupta, Anjali Pandey, Sarang Bani, Subhash C Taneja, Khurshid A. Bhat, Bhahwal A. Shah, Kuldeep K. Gupta, Anjali Pandey, Sarang Bani, Subhash C. Taneja

Index: Bioorg. Med. Chem. Lett. 19 , 1939-43, (2009)

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Abstract

Semi-synthetic analogs of pinitol were subjected to screening by determining TNF-alpha expression in human neutrophils using flowcytometry. Among the tested compounds, three derivatives displayed more than 50% inhibition of TNF-alpha cytokine secretion in LPS induced stimulated neutrophils and can be considered as potent anti-inflammatory moieties.