The Journal of organic chemistry

A Scalable, Nonenzymatic Synthesis of Highly Stereopure Difunctional C4 Secondary Methyl Linchpin Synthons

S Mekala, RC Hahn

Index: Nitta, Yoshihiro; Arakawa, Yasushi; Ueyama, Naoto Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 7 p. 2710 - 2718

Full Text: HTML

Citation Number: 2

Abstract

... Volume: Page: ... Department of Chemistry, Syracuse University ... a 9:1 or greater preference for bromide displacement, but direct OCas displacement by Nu − , along with attack on OCas by in situ generated Br – , appreciably degraded the chemical and optical ...

 Related Synthetic Route

~95%

~0%

~82%

~49%

~79%

~71%

~62%

~83%

~70%

~68%

~73%

~87%

Detail

~75%

~89%

~89%

~74%

~78%

~73%

~52%

~87%

~77%

~46%

~38%

~67%

~74%

~53%

~38%

~0%

Detail

~%

Detail

~0%

Detail

~%

Detail

~0%

Detail

~63%

~%

~57%

~%

~21%

Detail

~97%

~0%

~0%

Detail

~81%

~70%