Bioorganic & Medicinal Chemistry Letters 2003-06-16

Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors.

Stefan Jaroch, Peter Hölscher, Hartmut Rehwinkel, Detlev Sülzle, Gerardine Burton, Margrit Hillmann, Fiona M McDonald

Index: Bioorg. Med. Chem. Lett. 13(12) , 1981-4, (2003)

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Abstract

Dihydroquinolines with aminoalkyl side chains have been synthesized and have been shown to be potent n-NOS inhibitors. A marked selectivity versus e-NOS of up to approximately 300-fold was observed, whereas i-NOS was moderately inhibited.