International Journal of Pharmaceutics 2015-04-10

Hyperspectral imaging in quality control of inkjet printed personalised dosage forms.

Hossein Vakili, Ruzica Kolakovic, Natalja Genina, Mathieu Marmion, Harri Salo, Petri Ihalainen, Jouko Peltonen, Niklas Sandler

Index: Int. J. Pharm. 483(1-2) , 244-9, (2015)

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Abstract

The aim of the study was to investigate applicability of near infra-red (NIR) hyperspectral imaging technique in quality control of printed personalised dosage forms. Inkjet printing technology was utilized to fabricate escalating doses of an active pharmaceutical ingredient (API). A solution containing anhydrous theophylline as the model drug was developed as a printable formulation. Single units solid dosage forms (SDFs) were prepared by jetting the solution onto 1 cm × 1 cm areas on carrier substrate with multiple printing passes. It was found that the number of printing passes was in excellent correlation (R(2)=0.9994) with the amount of the dispensed drug (μg cm(-2)) based on the UV calibration plot. The API dose escalation was approximately 7.5 μg cm(-2) for each printing pass concluding that inkjet printing technology can optimally provide solutions to accurate deposition of active substances with a potential for personalized dosing. Principal component analysis (PCA) was carried out in order to visualize the trends in the hyperspectral data. Subsequently, a quantitative partial least squares (PLS) regression model was created. NIR hyperspectral imaging proved (R(2)=0.9767) to be a reliable, rapid and non-destructive method to optimize quality control of these planar printed dosage forms.Copyright © 2015 Elsevier B.V. All rights reserved.