Organic letters

Phase-vanishing methodology for efficient bromination, alkylation, epoxidation, and oxidation reactions of organic substrates

NK Jana, JG Verkade

Index: Jana, Nirmal K.; Verkade, John G. Organic Letters, 2003 , vol. 5, # 21 p. 3787 - 3790

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Citation Number: 81

Abstract

In cases where both reactants in a phase-vanishing reaction are less dense than the fluorous phase, an alternative to the U-tube method is to employ a solvent with greater density than the fluorous phase, such as 1, 2-dibromoethane. This modification has been successfully applied to the methylation of a phenol derivative with dimethyl sulfate and to the m-CPBA-induced epoxidation of alkenes, N-oxide formation from nitrogen-containing ...