Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group

…, M Kitagawa, Y Nagaoka, T Maeda, H Kuwajima…

Index: Uesato, Shinichi; Kitagawa, Manabu; Nagaoka, Yasuo; Maeda, Taishi; Kuwajima, Hiroshi; Yamori, Takao Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 10 p. 1347 - 1349

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Citation Number: 52

Abstract

Utilizing tranexamic acid as a starting material, a series of N-hydroxycarboxamides were synthesized in order to seek new histone deacetylase (HDAC) inhibitors. Further structure optimization involving the replacement of the 1, 4-cyclohexylene group with the 1, 4- phenylene group yielded the promising HDAC inhibitors which possess a terminal bicyclic aryl amide.