Despite the great interest in 3-aminopyrrole derivatives as building blocks in heterocyclic chemistry, access to these compounds remains quite difficult and the methods described fail for large scale. For example, only one synthesis of 3-amino-I-phenylpyrrole (9) has been reported;'it involves nitration of 1-phenylpyrrole (2), separation of the 2-and 3-nitropyrrole isomers, and subsequent hydrogenation of the latter to 9. The overall yield and ...
