Arkivoc

Synthesis of new selenophene and thiazole analogues of the Tacrine series

P Seck, D Thomae, E Perspicace, S Hesse, G Kirsch

Index: Seck, Pierre; Thomae, David; Perspicace, Enrico; Hesse, Stephanie; Kirsch, Gilbert Arkivoc, 2012 , vol. 2012, # 3 p. 431 - 441

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Abstract

Abstract New 2-aminoselenophene-3-carbonitriles and 5-amino-1, 3-thiazole-4-carbonitriles were made and reacted with cycloalkanones to give tetrahydroselenolo [2, 3-b] quinolines, cycloalkene-fused selenolo [3, 2-e] pyridines,[1, 3] thiazolo [5, 4-b] quinolines, thiazolo [4, 5- e] pyridines and tetrahydro-[1, 3] thiazolo [5, 4-b] quinolines. Keywords: 2- aminoselenophene-3-carbonitriles, 5-amino-1, 3-thiazole-4-carbonitriles, Gewald reaction ...