Tetrahedron letters

The synthesis of dibenzofuran based diacids and amino acids designed to nucleate parallel and antiparallel β-sheet formation.

H Diaz, JW Kelly

Index: Diaz, Humberto; Kelly, Jeffery W. Tetrahedron Letters, 1991 , vol. 32, # 41 p. 5725 - 5728

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Citation Number: 48

Abstract

Our understanding of parallel and antiparallel g-sheet secondary struchue in peptides and proteins lags significantly behind our comprehension of the a-helical sttucture because the development of p-sheet model systems have proven elusive. The inability to predict the locations of the required reverse turns or loops (the turn problem) and the tendency of g- sheets to aggregate, once formed, are impeding progress towards a well characterized g- ...