Hydrophobic cluster formation is necessary for dibenzofuran-based amino acids to function as. beta.-sheet nucleators

KY Tsang, H Diaz, N Graciani…

Index: Tsang, Kwok Yin; Diaz, Humberto; Graciani, Nilsa; Kelly, Jeffery W. Journal of the American Chemical Society, 1994 , vol. 116, # 9 p. 3988 - 4005

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Citation Number: 196

Abstract

Abstract: Three dibenzofuran-based amino acid residues, namely 4-(2-aminoethyl)-6- dibenzofuranpropanoic acid (l), 4-(aminomethyl)-6-dibenzofuranethanoic acid (2), and 4- amino-6-dibenzofuranmethanoic acid (3), were prepared in order to compare their physical properties so as to further understand residue 1's ability to nucleate antiparallel@-sheet formation within small peptides in aqueous solution. FT-IR, variable temperature NMR, ...