Regio-and stereoselective synthesis of the 1, 3-cyclohexadiene nucleus by [2+ 2+ 2] cycloaddition reactions catalyzed by titanium aryloxide compounds

ES Johnson, GJ Balaich…

Index: Johnson, Eric S.; Balaich, Gary J.; Rothwell, Ian P. Journal of the American Chemical Society, 1997 , vol. 119, # 33 p. 7685 - 7693

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Citation Number: 65

Abstract

A variety of titanium aryloxide reagents catalyze the cross coupling of two alkyne units with 1 equiv of olefin to produce the 1, 3-cyclohexadiene nucleus. Catalysts include isolated titanacyclopentadiene or titanacyclopentane complexes. The reaction proceeds via attack of the olefin upon a titanacyclopentadiene compound initially formed by coupling of two alkyne units. The reaction is limited to bulky alkyne substrates that undergo slow catalytic ...