Retinobenzoic acids. 5. Retinoidal activities of compounds having a trimethylsilyl or trimethylgermyl group (s) in human promyelocytic leukemia cells HL-60

T Yamakawa, H Kagechika, E Kawachi…

Index: Yamakawa, Takeru; Kagechika, Hiroyuki; Kawachi, Emiko; Hashimoto, Yuichi; Shudo, Koichi Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1430 - 1437

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Citation Number: 80

Abstract

2 same The generic chemical structure of retinobenzoic acids is represented by 2.1 Groups necessary for retinoidal activities are a bulky alkyl group, such as an isopropyl or a tert-butyl group, at the meta (R,) position on one benzene ring and a carboxyl group at the para position of the other benzene ring. The linking group X can be varied (such as-NHC0-, l'J2- CONH-, 12J3-SO, NH-,-COCH= CH-) 14J5-N= N-, 16J7 and so forth), regardless of the ...