Efficient synthesis of structurally diverse diazabicycloalkanes: scaffolds for modular dipeptide mimetics with tunable backbone conformations

…, DC Grohs, AHGP Prenzel

Index: Maison, Wolfgang; Grohs, Daniel C.; Prenzel, Alexander H. G. P. European Journal of Organic Chemistry, 2004 , # 7 p. 1527 - 1543

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Citation Number: 14

Abstract

Abstract A stereoselective synthesis of new dipeptide mimetics based on a diazabicycloalkane scaffold is reported. The route starts from enantiomerically pure azabicycloalkenes 1 that are bis (hydroxylated) and coupled N-terminally to a second amino acid. The key step of the reaction sequence is an oxidative cleavage of the resulting dipeptides 5 to give highly functionalised diazabicycloalkanes 6, which can be easily ...