Synlett

FeCl3-catalyzed reduction of ketones and aldehydes to alkane compounds

C Dal Zotto, D Virieux, JM Campagne

Index: Dal Zotto, Christophe; Virieux, David; Campagne, Jean-Marc Synlett, 2009 , # 2 p. 276 - 278

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Citation Number: 14

Abstract

In the context of the development of iron-catalyzed reactions, [6] we planned to use the Lewis acid character of the iron salts to promote a further reduction of the O-silylated intermediate 2 in order to obtain the methylene derivative 3 (Scheme [¹] ). The defunctionalization of ketones to methylenes is a key reaction in the organic chemist tool box and many methodologies have been described in the literature. The textbook Clemensen [7] and Wolff-Kischner [8] ...