Inhibitory effects of lapachol derivatives on epstein-barr virus activation

EP Sacau, A Estévez-Braun, ÁG Ravelo…

Index: Sacau, Elisa Perez; Estevez-Braun, Ana; Ravelo, Angel G.; Ferro, Esteban A.; Tokuda, Harunkuni; Mukainaka, Teruo; Nishino, Hoyoku Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 4 p. 483 - 488

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Citation Number: 97

Abstract

Sixteen derivatives (2–17) synthesized from the naphthoquinone lapachol (1), were tested for their inhibitory effects on Epstein–Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), as a test for potential cancer chemopreventive agents. They exhibited a variety of inhibitory activities from very high to moderate, which allow us to suggest structure–activity relationships. Ten of these derivatives are reported ...