A new approach to rapid parallel development of four neurokinin antagonists. Part 2. Synthesis of ZD6021 cyano acid

JD Moseley, WO Moss, MJ Welham…

Index: Organic Process Research and Development, , vol. 7, # 1 p. 58 - 66

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Citation Number: 10

Abstract

... 13 Clearly we could have accommodated this process, since this method was used for the later amide bond-forming reaction, 3 but we felt in this case that a simpler procedure could just as ... This process typically gave a near quantitative yield with organic purity >90 ...